Supplementary Figure 8: Schematic model of the role of PTGER2 and the AKT–β-catenin–SGK1–Foxo axis in the production of IFN-γ and IL-10 in Treg cells.
From: Activated β-catenin in Foxp3+ regulatory T cells links inflammatory environments to autoimmunity
AKT-β-catenin signaling balances between IFN-γ and IL-10 production in Treg cells. Under high salt conditions, PTGER2 was increased and established the positive feed forward loop with β-catenin, resulted in amplified activation of the β-catenin-SGK1-Foxo axis in IFN-γ-producing Treg cells.
