Supplementary Figure 2: Transcriptome (RNA-seq) of CNS-onset Ly6G⁺ cells and CNS-recovery Ly6G⁺ cells.

a,b, Waterfall plot of log₂ fold change in gene expression comparing CNS-onset Ly6G⁻tdTomato⁺ cells versus spleen-onset Ly6G-tdTomato⁺ cells (a) and CNS-recovery Ly6G-tdTomato⁺ cells versus spleen-onset Ly6G-tdTomato⁺ cells (b). The positions of Nos2 (inducible NO synthetase) and Arg1 (arginase 1) are indicated. c,d, Heatmaps of gene expression in Ly6G-tdTomato⁺ subsets for top three significantly enriched gene ontology terms (GOrilla) in universally downregulated (c) and upregulated (d) genes in CNS-onset Ly6G-tdTomato⁺ cells versus all other Ly6G-tdTomato⁺ cell subsets (see Fig. 3a).