Supplementary Figure 3: Untargeted metabolomic profiling of WT and Ido1–/– macrophages.
From: Macrophage de novo NAD+ synthesis specifies immune function in aging and inflammation
a, Hierarchical clustering of validated and significantly altered metabolites (q < 0.05) are represented. Ido1–/– macrophages show disrupted amino acid metabolism and lipid metabolism and increased glycolysis (n = 8 mice per group, two-tailed parametric Welch’s T-test with multiple-hypothesis q-value correction. FDR < 0.05 was considered significant). b, MBROLE enrichment analysis of untargeted metabolomics from comparison of Ido1–/– versus WT macrophages (n = 8 per genotype).
