Supplementary Figure 1: Functional enrichment analysis in patients characterized by computational separation of T cell anti-tumor immunity.
From: Uncoupling protein 2 reprograms the tumor microenvironment to support the anti-tumor immune cycle
a, Gene ontology term enrichment analysis for top 20 biological process controlled by differentially expressed genes between of patients with either high or low combined score for T cell anti-tumor immunity. Top panel: top 20 up-regulated biological processes in patients with high T cell anti-immunity. Bottom panel: top-20 up-regulated biological processes genes in patients with low T cells anti-tumor immunity. b, Pearson correlation plots of expression of other members of UCP family, including UCP1, UCP3, UCP4 or UCP5, with transcripts of CD8A, IFNG, GZMB, TNF, LCK, and SYK. Data were analyzed form 472 melanoma patients in TCGA database (biologically independent melanoma tumor samples), and analyzed by Pearson correlation coefficient.
