Supplementary Figure 7: Lineage trees of SED and GC B cells. | Nature Immunology

Supplementary Figure 7: Lineage trees of SED and GC B cells.

From: BCR affinity differentially regulates colonization of the subepithelial dome and infiltration into germinal centers within Peyer’s patches

Supplementary Figure 7

a,b, Additional supporting data for Fig. 7. All IgA+ B cell clones analyzed from sequences derived from single-sorted cells of the SED and GC compartments, as described in Fig. 7 and in the Methods section. The number of mutations between neighboring nodes is indicated and includes synonymous, non-synonymous, and reverse mutations to the germline sequence. GL, germline. UCA, unique common ancestor, inferred from the sequence analysis. Lineage-trees are shown from two independent experiments with one PP from one mouse in each experiment (n=2), shown as (a) and (b).

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