Supplementary Figure 5: Core exacerbation modules are common to exacerbation events with or without virus present, while additional distinct patterns of module expression are unique to V+Ex+ and V-Ex+ events.
From: Transcriptome networks identify mechanisms of viral and nonviral asthma exacerbations in children
(a) The core exacerbation modules show a similar degree of altered expression in both V+Ex+ (n = 33) and V-Ex+ (n = 14) events and are significant in each subgroup comparison. (b) V+Ex+ events demonstrate specific upregulation in 9 modules that represent numerous inflammatory pathways and specific downregulation in 2 modules. (c) V-Ex+ events demonstrate specific upregulation of 3 squamous cell associated modules. Expression levels represent the geometric mean of the normalized expression of all genes within the module. Shown are subgroup mean and standard error values. All modules shown have an ANOVA FDR<0.05. FC and FDR values are listed in Table 2. This analysis included 247 unique nasal samples and 256 unique blood samples from 106 individuals who in total had 33 V+Ex+, 14 V-Ex+, 69 V+Ex- and 38 V-Ex- events.
