Supplementary Figure 8: Schematic representation of the effect of rs1015164A/G variant on HIV infection.
From: CCR5AS lncRNA variation differentially regulates CCR5, influencing HIV disease outcome
The rs1015164A/G variant associates with CCR5AS expression, where rs1015164A marks high CCR5AS expression. High CCR5AS expression enhances CCR5 expression post-transcriptionally by sequestering the RNA binding protein Raly, inhibiting the binding of Raly to the CCR5 3’UTR, and protecting CCR5 mRNA from Raly-mediated decay. Higher expression levels of CCR5AS result in increased cell surface expression of the HIV co-receptor CCR5 and higher levels of HIV infection, providing the functional basis for the association between rs1015164A and poor HIV control.
