Supplementary Figure 12: Histological analysis of tissues from Tnfaip3I207L and Tnfaip3C243Y mice.
From: Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity
(a) Body weights of 8 week-old Tnfaip3I207L and Tnfaip3C243Y mice of the indicated genotype and sex. Bars represent mean ± s.e.m. Statistical analysis by one-way ANOVA: ****P < 0.0001. Hematoxylin and eosin (H&E) stained sections from Tnfaip3I207L mice of the indicated genotypes, including colon (b) (20× magnification; scale bar = 200 µm; see Fig. 6d for C243Y genotype), kidney (c) (4× top panel, scale bar = 500 µm; 10× bottom panel, scale bar = 200 µm), liver (d) (4× top panel, scale bar = 500 µm; 10× bottom panel, scale bar = 200 µm), and pancreas (e) (10× images, scale bar = 200 µm). Images are representative from 16 week old mice of the indicated genotype (n=4).
