Supplementary Figure 1: Evolutionary conservation of A20 OTU alleles amongst jawed vertebrates and global distribution of the T108A;I207L TNFAIP3 haplotype.
From: Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity
(a) Aligned amino acid sequence and secondary structure elements of the A20 OTU domain, from40. T108, I207, C243 and I325 residues are boxed in red (b) gnomAD r2.0.2 population allele frequencies for the T108A and I207L missense alleles in TNFAIP3, with allele counts above each bar (total alleles as denominator). Populations were defined by principal component clustering of samples with individuals of known ancestry: those which do not cluster fall into the OTH group. AFR, African; AMR, Latino; ASJ, Ashkenazi Jew; EAS, East Asian; FIN, Finnish European; NFE, non-Finnish European; OTH, other; SAS, South Asian. The OTH population includes one homozygote, while all other alleles are heterozygous. (c) Frequency of the T108A;I207L TNFAIP3 haplotype within 279 individual genomes from the Simons Genome Diversity Project22.
