Extended Data Fig. 6: Human variation in CRELD1 expression reflects transcriptional changes in Creld1 cKO.
From: CRELD1 modulates homeostasis of the immune system in mice and humans
a, Schematic representation of the selection of genes used for the cKO DOWN and cKO UP signatures. b, Schematic overview of the analysis performed on the CEDAR dataset. Gene set variation analysis performed on all healthy donors in the CEDAR cohort for both (c) cKO UP and (d) cKO DOWN signatures vs. CRELD1 expression (error bar shows 95th confidence interval, p-value shown for Pearson’s correlation test). e, Schematic overview of the analysis performed on the ImmVar dataset. f, g, Gene set enrichment analysis (GSEA) of the ImmVar CD4+ T cell samples in the CRELD1lo vs. CRELD1hi comparison for the (f) ‘cKO UP’ and ‘cKO DOWN’ gene signatures as well as (g) selected apoptosis and WNT signaling signatures (p-value derived from statistical summary of GSEA). h, GSEA of the conventional monocyte samples of the ImmVar dataset in the CRELD1lo vs. CRELD1hi comparison for the ‘cKO UP’ and ‘cKO DOWN’ gene signatures (p-value derived from statistical summary of GSEA). i, Schematic overview of the analysis performed on our curated PBMC dataset collection.
