Fig. 1: Children with and without MIS-C exhibit distinct SARS-CoV-2 antibody profiles compared to adults with COVID-19. | Nature Immunology

Fig. 1: Children with and without MIS-C exhibit distinct SARS-CoV-2 antibody profiles compared to adults with COVID-19.

From: Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum

Fig. 1

a–d, Levels of antibodies to SARS-CoV-2 S and N proteins were measured using serial dilutions of patient plasma in an indirect ELISA assay to detect anti-S IgG (a), anti-S IgM (b), anti-S IgA (c) and anti-N IgG (d). The absorbance sum across 6 serial 1:4 plasma dilutions from adult CPDs (open black squares, n = 19), adult patients with COVID-19-induced ARDS (COVID-ARDS, closed red squares, n = 13), pediatric patients with a history of SARS-CoV-2 infection but not MIS-C (non-MIS-C, open blue circles, n = 31), patients with MIS-C (closed green circles, n = 16) and control plasma from pre-pandemic donors (negative control, gray triangles, n = 10) is shown. The black bar indicates the median + interquartile range (IQR). P values were calculated by one-way ANOVA with Šidák’s multiple comparisons test. Anti-S IgG (a): CPD versus COVID-ARDS: P = 1.32 × 10−4; CPD versus pediatric non-MIS-C: P = 0.59; COVID-ARDS versus MIS-C: P = 8.53 × 10−6; pediatric non-MIS-C versus MIS-C: P = 0.24. Anti-S IgM (b): CPD versus COVID-ARDS: P = 6.93 × 10−5; CPD versus pediatric non-MIS-C: P = 0.33; COVID-ARDS versus MIS-C: P = 2.54 × 10−6; pediatric non-MIS-C versus MIS-C: P = 0.99. Anti-S IgA (c): CPD versus COVID-ARDS: P = 3.82 × 10−7; CPD versus pediatric non-MIS-C: P = 0.08, COVID-ARDS versus MIS-C: P = 9.06 × 10−7; pediatric non-MIS-C versus MIS-C: P = 0.11. Anti-N IgG (d): CPD versus COVID-ARDS: P = 0.93; CPD versus pediatric non-MIS-C: P = 3.31 × 10−5; COVID-ARDS versus MIS-C: P = 3.88 × 10−5; pediatric non-MIS-C versus MIS-C: P = 0.99. Significance is indicated as ***P < 0.001 or P > 0.05 (not significant (NS)). e,f, For anti-S IgG (e) and anti-N IgG (f), the antibody levels of individuals are also plotted against patient age in the adult (left) and pediatric cohorts (right) with the best fit lines and P values calculated using simple linear regression. Anti-S IgG versus age (pediatric non-MIS-C: R2 = 0.23, slope = −0.077, y-intercept = 2.70). Anti-N IgG versus age (CPD: R2 = 0.34, slope = 0.023, y-intercept = 0.12).

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