Extended Data Fig. 5: NIK-mediated stimulation of antitumor T cell responses requires HK2.
From: NF-κB-inducing kinase maintains T cell metabolic fitness in antitumor immunity
Flow cytometric analysis of the frequency and absolute cell number of CD4 and CD8 T cells (a), PD1+Tim3+ CD8 T cells (b) and flow cytometric analysis of the expression level (MFI) of PD1 and Tim3 in CD8 T cells (c) in day-27 tumor of wildtype (WT), NIKiTg (iTg), NIKiTgHk2iKO (iTg-iKO) mice injected s.c. with 5 × 105/mouse MC38 colon cancer cells (a,b, WT: n = 4; iTg: n = 4; iTg-iKO: n = 3). Data are representative of two independent experiments. Summary data are shown as mean ± s.e.m. with P values were determined by two-tailed Student’s t test.
