Extended Data Fig. 3: γδTN cells can generate γδ17 and γδIFN T cells. | Nature Immunology

Extended Data Fig. 3: γδTN cells can generate γδ17 and γδIFN T cells.

From: Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments

Extended Data Fig. 3

Flow cytometry profiles of thymic γδ T cells from E15 thymic lobes that had been cultured for 7-days in fetal thymic organ culture (E15 + 7dFTOC). CD24+ (γδ24+) precursors downregulate CD24 to become a CD24-CD44-CD45RB- (γδTN) population. γδTN cells are able to become either IL-17-secreting CD44+CD45RB- γδ17 cells, or IFN-γ-producing CD44+CD45RB+ γδIFN cells.

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