Extended Data Fig. 1: Role for type I IFN in disease phenotypes of Irgm1^−/− mouse.

a, Expression of interferon-stimulated genes in bronchoalveolar lavage (BAL) cells, bone marrow cells, and spleen of wild type and Irgm1^−/− animals (n = 3/genotype). b, Autoantibodies against full array of 124 antigens, measured in serum of animals (n = 3–4 mice/genotype; each column is an independent mouse). c, Total count of bone marrow cells in wild type (n = 8), Irgm1^−/−(n = 8), and Irgm1^−/−Ifnar^−/− (n = 9) mice. d, Total leukocyte count (WBC), lymphocyte count, platelet count, hemoglobin concentration, and hematocrit in peripheral blood of wild-type (n = 5), Ifnar^−/− (n = 3), Irgm1^−/−(n = 8), and Irgm1^−/−Ifnar^−/− (n = 6) mice. Data are mean + /− s.e.m. *P < 0.05, **P < 0.01, ***P < 0.001. Two-tailed unpaired t-test (a, d) and one-way ANOVA with Tukey’s adjustment (c).