Extended Data Fig. 4: Basophils are sufficient to limit helminth-induced ILC2 responses.
From: Basophils prime group 2 innate lymphoid cells for neuropeptide-mediated inhibition
a, ILC2 numbers, (b), ILC2 production of IL-5, and (c), IL-13, as well as (d) eosinophil numbers were quantified in the lung on day 7 post-Nb infection in control mice, baso-dep mice, or baso-dep mice that received adoptive transfers of basophils. e, H&E staining of lung sections on day 7 post-Nb infection with individual images digitally tiled together to provide a larger overview. Mucus production in the lung was evaluated by (f), PAS staining of lung sections and (g), Muc5ac expression. P values were determined by two-tailed Student’s t-tests. *P < 0.05, **P < 0.01, ***P < 0.001. a-g, Representative of at least 3 separate experiments with at least 4 mice per group.
