Extended Data Fig. 9: Integrated scRNA-seq analysis across atherosclerosis progression. | Nature Immunology

Extended Data Fig. 9: Integrated scRNA-seq analysis across atherosclerosis progression.

From: Limited proliferation capacity of aortic intima resident macrophages requires monocyte recruitment for atherosclerotic plaque progression

Extended Data Fig. 9

(a) scRNA-seq data from sorted CD45+ aorta cells isolated from C57Bl/6, 21-day HFD Ldlr−/−, and 12-week HFD Ldlr−/− mice was integrated and clustered into 16 populations. (b) All clusters were represented across unique time points. (c) MacAIR geneset (Mmp12, Il1b, Lgals3, Nes, Rgs1, Acp5, Asb2, Itgax, Cadm1, Gngt2, Cd9, Bcl2a1a) expression analysis of integrated cluster map and across time points. (d) Foamy macrophage geneset (Fabp4, Ctsl, Atp6v0d2, Gpnmb, Fabp5, Htra1, Epb41l3, Pld3) expression analysis of integrated cluster map and across time points. (e) Human foamy macrophage geneset (Gpx1, Pfdn5, Tpt1, Eef1a1, Ctb, B2m, Tmsb4x, Fth1, Ftl, Tmsb10, Cd63, Lgals1, Fcer1g, Npc2, Serf2, Ybx1, Psap, Apoc1, Apoe, Cstb, Ctsb, Vim, RnaseI, Fabp5, Plin2, Ccl2) expression analysis in the murine integrated scRNA-seq cluster map, suggesting shared gene expression programs between human and murine foamy macrophage subsets.

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