Extended Data Fig. 4: MDR/MGlo populations of CD8+ T cells in spleens and dLNs.
From: Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion
a, MDR/MGlo populations in activated OT-I and P14 CD8+ T cells isolated from spleens and dLNs either on YUMM1.7-OVA side or YUMM1.7-gp33 side were determined using flow cytometry. Each line indicates paired activated CD8+ T cells from same tissue (Spleen and dLN from OVA side: n = 8 per group; dLN from gp33 side: n = 7 per group). b, MDR/MGlo populations in activated OT-I and OT-3 CD8+ T cells from spleens and dLNs of YUMM1.7-OVA melanoma-engrafted mice were determined using flow cytometry. Each line indicates paired activated CD8+ T cells from same tissue (Spleen, n = 10; dLN, n = 8). c, MDR/MGlo populations in activated WT and PD-1 KO CD8+ T cells from spleens and dLNs were determined using flow cytometry. Each line indicates paired activated CD8+ T cells from same tissue (Spleen, n = 7; dLN, n = 8). All data were analyzed by two-tailed, unpaired Student’s t-test.
