Extended Data Fig. 6: Altered chromatin accessibility in in vitro-activated CD8+ T cells with depolarized mitochondria.
From: Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion
a, Distributions of differentially accessible peaks specific to MDR/MGhi or MDR/MGlo CD8+ T cells generated by oligomycin A/Mdivi-1 treatment. b, Bar graphs represent NCI-Nature 2016 pathways that are enriched among genes assigned to differentially accessible peaks in MDR/MGhi and MDR/MGlo CD8+ T cells generated by oligomycin A/Mdivi-1 treatment with indicated adjusted P-value. Enrichment was calculated using the Enrichr tool. c, Representative ATAC-seq tracks at Tcf7 and Lef1 loci from sorted MDR/MGhi or MDR/MGlo CD8+ T cells generated by oligomycin A/Mdivi-1 treatment.
