Extended Data Fig. 5: MAIT cell function alterations in blood and bronchoalveolar lavage.
From: Outcome of SARS-CoV-2 infection is linked to MAIT cell activation and cytotoxicity
a, Flow cytometry analysis of IFNγ, TNF, IL-2, IL-4, IL-10, IL-17, and granzyme B production among stimulated MAIT cells, conventional CD8+ and CD4+ T cells, γδ T and CD3− cells from IDU (n = 15-16) or ICU COVID-19 patients (n = 19). b, Flow cytometry analysis of GzB without stimulation from IDU (n = 11) or ICU COVID-19 patients (n = 14). c, Flow cytometry analysis of IL-17+, IFNγ+, and double positive MAIT cells from Uninfected patients(n = 30), IDU (n = 11) or ICU COVID-19 patients (n = 14). d, Flow cytometry analysis of MAIT cells and GzB+ MAIT cells frequencies in BAL fluids (Bronchoalveolar lavage) from 3 COVID-19 patients admitted in ICU and compared to their respective blood counterpart. Each symbol represents a single biological sample. *P < 0.05 and **P < 0.01 (two-sided Mann-Whitney nonparametric test (a-c) or Wilcoxon signed-rank test (d)).
