Fig. 3: MAIT cells phenotype correlates with ILC and γδ T cell alteration in patients with COVID-19.

a,b, Frequencies of NK, ILC2 and ILC3 innate immune cells among CD3^–CD19^– cells (a) and CD69 activation surface markers on NK, ILC2, ILC3 and γδ T cells (b) in uninfected controls (n = 80) and patients with COVID-19 hospitalized in an IDU (n = 62) or ICU (n = 66). c, Multiparametric matrix correlation plot of MAIT cell, γδ T cell, ILC and NK cell frequencies, and surface marker and intracytoplasmic staining in patients with COVID-19. Spearman’s correlation coefficients are visualized by square size and color intensity. Variables are ordered by hierarchical clustering. d, Correlation between CD69⁺ MAIT cells and CD69⁺ NK, CD69⁺ ILC3 or CD69⁺ γδ T cells in patients with COVID-19 (n = 102). Small horizontal lines indicate the median and quartiles (a and b). Each symbol represents one biological sample. *P < 0.05, **P < 0.01, ***P < 0.001 and ****P < 0.0001 (two-sided Mann–Whitney non-parametric test (a and b) and Spearman’s non-parametric correlation test corrected for multiple inferences using Holm’s method (c and d)).