Extended Data Fig. 3: Creation of Irf8 enhancer-null mice by CRISPR/Cas9 genome editing.
From: A RUNX–CBFβ-driven enhancer directs the Irf8 dose-dependent lineage choice between DCs and monocytes
a, The Genome Browser image of the regions deleted in each enhancer-null mouse strain. b, Representative cropped gel images of genomic PCR confirming the deletion. Primer sets are indicated. Data are representative of over 20 independent experiments for each genotype, which yielded similar results. Full scans are shown in Source Data. c, The Genome Browser image of input DNA data at the Irf8 gene locus on ∆+56 cMoP in ChIP-seq analysis. Gray boxes indicate known enhancers at –50, +41, and +32 kb.
