Extended Data Fig. 10: Schematic model of the DAPK3-STING axis.
From: The tumor suppressor kinase DAPK3 drives tumor-intrinsic immunity through the STING–IFN-β pathway
In unstimulated cells (L929 and MCA205), DAPK3 maintains steady-state STING levels by inhibiting STING K48-linked poly-ubiquitination and proteasome-mediated degradation. In DNA-stimulated cells (THP1), DAPK3 promotes STING activation by phosphorylating the E3 ligase LMO7 at S863, enabling LMO7-STING interaction, STING K63-linked poly-ubiquitination, and recruitment of TBK1.
