Extended Data Fig. 4: The effect of metformin on NLRX1 expression in CD4 T cells.
From: Multi-omics analyses reveal that HIV-1 alters CD4+ T cell immunometabolism to fuel virus replication
a–d, CD3/CD28 antibody-activated human primary CD4 T cells were left uninfected (a) or infected by three different HIV-1 clinical isolates, #409 (b), #413 (c), and #414 (d) in the presence of 5 mM metformin or the vehicle control, sterile water. NLRX1 transcripts were assessed at 48 hpi by qPCR. Representative data of three independent experiments are shown as the mean ± standard deviation (s.d). n = 4 cell cultures per experiment. Statistical significance was tested by two-tailed unpaired Student’s t-test.
