Extended Data Fig. 5: Silencing NLRX1 protects HIV-1 caused human CD4 T cell depletion in the NRG-hu CD4 mouse model.
From: Multi-omics analyses reveal that HIV-1 alters CD4+ T cell immunometabolism to fuel virus replication
a, Representative fluorescence-activated cell sorting (FACS) plot of human CD4 T cells expressing the indicated markers in peripheral blood from mock or HIV-1 R3A infected NRG-hu CD4 mice at 1 and 2 wpi. b, Spleens from mock or HIV-1 R3A infected NRG-hu CD4 mice at 3 wpi. n = 6 mice per group. c, Splenocyte numbers of mock or HIV-1 R3A infected NRG-hu CD4 mice at 3 wpi. The data are a pool of two independent experiments. n = 8 mice for mock groups; n = 9 mice for HIV-1 infection groups. Data are presented as the mean ± s.e.m. Statistical significance was tested by two-way ANOVA followed by Sidak’s multiple comparisons test.
