Fig. 1: Robust T cell immunity against SARS-CoV-2 is present in all donors at 6 months following primary infection.
From: Robust SARS-CoV-2-specific T cell immunity is maintained at 6 months following primary infection
a, ELISPOT responses against SARS-CoV-2 protein pools at 6 months following primary infection. A representative ELISPOT from 1 of 95 donors against spike (pools 1 and 2), N/M and accessory proteins (ORF3a, ORF10, NSP8, NSP7A/b), with DMSO as negative control and CEFX peptide pools and anti-CD3 as positive controls (left). Summary data of all patients (n = 95) studied according to spike, N/M and accessory peptide pools (right). Data in graph represented as s.f.c. per million PBMCs. Each point on violin plot represents a single donor. Bold black line represents the median. The significance between pools was determined using a Friedman test (two-sided) with Dunn’s multiple comparison test, ****P < 0.0001; NS, not significant. DMSO, dimethylsulfoxide; s.f.c., spot-forming cells. b, Aggregate ELISPOT response against SARS-CoV-2 proteins at 6 months following primary infection. The spot numbers were aggregated for individual donors and shown in a bar chart.
