Extended Data Fig. 5: Comparison of lymphoid cellularity upon Grem1+ FRC ablation.
From: Gremlin 1+ fibroblastic niche maintains dendritic cell homeostasis in lymphoid tissues
a, Relative proportion (top row) and absolute numbers (bottom row) of indicated cell subsets in lymph nodes of Grem1-Cre-ERT2 Rosa26 EYFP (n = 12) and Rosa26 EYFP/iDTR (n = 14) mice upon DTxn mediated ablation. b, Representative plot with relative proportion of EYFP (Grem1) expression on CD11chi MHCIIinter cDCs in lymph nodes of Grem1-Cre-ERT2 Rosa26 EYFP (n = 5) mice. c, Relative proportion (top row) and absolute numbers (bottom row) of CD8a+ (left column) or CD11b+ CD4+ (right column) cDCs in spleens of Grem1-Cre-ERT2 Rosa26 EYFP (n = 12) and Rosa26 EYFP/iDTR mice (n = 14) upon DTxn mediated ablation d, Total cell numbers (top, left) and relative proportions of B cells (top, right), CD4+ T (bottom, left) and CD8+ T (bottom, right) in lymph nodes of Grem1-Cre-ERT2 Rosa26 EYFP (n = 7) and Rosa26 EYFP/iDTR (n = 9) mice at day 5 post-DTxn mediated ablation. Data are pooled from three independent experiments (a, c); representative of three independent experiments (b); data are pooled from two independent experiments (d). ****P < 0.0001, ***P < 0.001, *P < 0.05 (two-tailed unpaired Student’s t-test). Exact P-values in extended source data. Data are shown as mean ± SEM.
