Extended Data Fig. 8: Decreased CD4/CD8 T cell responses upon Grem1+ FRC depletion.
From: Gremlin 1+ fibroblastic niche maintains dendritic cell homeostasis in lymphoid tissues
a, schematic of anti-DEC205−OVA immunization protocol. b, relative proportion (top row) and absolute numbers (bottom row) of IFNg+ OT-I T cells in lymph nodes (left column) and spleen (right column) of Grem1-Cre-ERT2 Rosa26 EYFP (n = 5) and Rosa26 EYFP/iDTR (n = 5) at day 8 after DTxn mediated ablation. c, schematic of CFA/OVA immunization protocol. d, relative proportion (top) and absolute numbers (bottom) of transferred Thy1.1 OT-I T cells (left) or transferred labeled OT-II T cells (right) in spleen of Grem1-Cre-ERT2 Rosa26 EYFP (n = 5) and Rosa26 EYFP/iDTR (n = 5) at day 7 after DTxn mediated ablation. Data are representative of two independent experiments (b, d). **P < 0.01, *P < 0.05 (two-tailed unpaired Student’s t-test). Exact P-values in extended source data. Data are shown as mean ± SEM.
