Extended Data Fig. 2: The levels of chemokines and their corresponding receptors are equivalent in the tumor with high and low TI-TH1/ CTL infiltration. | Nature Immunology

Extended Data Fig. 2: The levels of chemokines and their corresponding receptors are equivalent in the tumor with high and low TI-TH1/ CTL infiltration.

From: Targeting regulator of G protein signaling 1 in tumor-specific T cells enhances their trafficking to breast cancer

Extended Data Fig. 2

a, Relative quantification of CCL3, CCL4, CCL5, CXCL9, CXCL10, CXCL11, CCL22 and CXCL12 mRNA in breast cancer tissues with low and high TI-TH1/ CTLs were examined by RT-qPCR (mean±s.e.m., n = 24; Breast cancer tissues with low TI-TH1 cells: n = 15; Breast cancer tissues with high TI-TH1 cells: n = 9; Breast cancer tissues with low TI- CTLs: n = 15; Breast cancer tissues with high TI-CTLs: n = 9). b, Representative plots of CXCR3, CCR4, CCR5 and CXCR4 expression in TH1 cells and CTLs isolated from breast cancer with low and high TI-TH1/CTLs, were determined by flow cytometry. The lower bar graph corresponds to the mean fluorescence intensity (MFI) (mean±s.e.m., n = 5).

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