Extended Data Fig. 8: RipIL-33 pathway for environmental allergen sensing.
From: Environmental allergens trigger type 2 inflammation through ripoptosome activation
Allergen exposure triggers RIP phosphorylation and ripoptosome assembly: RIP (RIP) in complex with cFLIPL, FADD, TRADD, and pro-caspase 8. Following RIP phosphorylation (pRIP), FADD-bound pro-caspase 8 is self-cleaved and activated. Active caspase 8 cleaves and deactivates pRIP and activates effector pro-caspases 3 and 7. Active effector caspases in turn target and cleave histone-bound pIL-33 at amino acids D175 and D178. mIL-33 is released to initiate type 2 innate immune responses.
