Extended Data Fig. 2: Viral infection after CVI reduces tight junction protein expression.
From: Antimicrobial immunity impedes CNS vascular repair following brain injury
a. Axial confocal images show i.v. injected tomato lectin (green), claudin-5 (red) and ZO-1 (white) in the superficial neocortex of uninfected (Ctrl) and d4 LCMV-infected B6 mice at day 20 post-CVI. Scale bar, 50 μm. b, c. Dot plots show image-based quantification of claudin-5 (b) and ZO-1 (c) sum intensity per vascular volume. Data represent a compilation of two independent experiments. Each symbol represents an individual mouse and asterisks denote statistical significance. Data are represented as mean ± SD. (Ctrl n=6, LCMV n=8; **P<0.01, ***P<0.0001; Two-tailed Student’s t-test). Source data for b,c in Source Data Extended Data Fig. 2.
