Extended Data Fig. 9: Related to Fig. 7.
Extended Data Figure 9a, Box plots of cluster coreness comparing DNA elements with OCT2-OCAB (n = 6768) or without OCT2-OCAB (n = 69469). P-values are calculated by Mann-Whitney U test. Box plots show center line as median, box limits as upper and lower quartiles, and whiskers as minimum and maximum values within 1.5 x inter-quartile range of 1st and 3rd quartile. b, box plots showing log2 fold change in histone H3K27ac ChIP-seq enrichment in GCBs (n = 4) vs NBs (n = 4) for clustered sites with or without OCT2-OCAB binding. P-value is computed by Welch’s t-test. c, genome browser plot of the BCL6 locus. d, Venn diagram of super-enhancers (SEs) in NBs and GCBs. e, plot of enhancers and SEs (red points) in GCBs. f, empirical cumulative distribution plot of contact distance for EP loops. P-value is calculated by Mann-Whitney U test. g, APA plots of GC-activated SE loops in control and OCABi OCI-Ly7 cells. h, bar plot of H3K27ac HiChIP APA scores for 621 GC-activated SE loops in OCI-Ly7 control (n = 3) or OCABi (n = 2) cells. P-value is calculated by t-test and error bars show standard error of the mean. i, GSEA enrichment plot using expression change in OCABi vs control for target genes of GC-activated SEs. j, Scatter plot showing per-gene aggregate HiChIP contact enrichment log2 fold changes in OCI-Ly7 OCABi vs Control. k, Scatter plot of aggregate H3K27ac ChIP-seq log2 fold changes in GCBs vs NBs for sites within a SE. Red and blue points indicate SEs above the 90th and below the 10th percentile, respectively. l, Super-enhancer analysis using the ROSE method with GCB OCT2 ChIP-seq signal over stitched GCB OCT2 ChIP-seq peaks. m, scatter plot showing the number of called H3K27ac Hi-ChIP enhancer-promoter loops per gene promoter for genes expressed in OCI-Ly7 cells.
