Extended Data Fig. 8: Additional CREB1 related cytokines are induced in immune cells stimulated with cGAMP. | Nature Immunology

Extended Data Fig. 8: Additional CREB1 related cytokines are induced in immune cells stimulated with cGAMP.

From: The transcription factor CREB1 is a mechanistic driver of immunogenicity and reduced HIV-1 acquisition following ALVAC vaccination

Extended Data Fig. 8

a, Median fold induction for all measured cytokines in purified DCs and CD4 + T cells treated with 10 uM cGAMP for 24 hours. b, TRAIL, GROα (CXCL1) and TGF-β1 which were all identified as positive correlates of V1V2 in Study 36 are also significantly induced by cGAMP treatment of purified DCs (black) and CD4 + T cells (blue) (n = 9), when these two groups are combined as distinct biological samples. Statistics performed using two-sided, paired t-test Lower line in violin plot is Q1, middle line is median and upper line is Q3. c, Proposed model of ALVAC induced CREB1 activation in mediating protective vaccine responses.

Back to article page