Extended Data Fig. 8: Transcriptome analysis of IECs after allo-HCT.
From: Mitochondrial complex II in intestinal epithelial cells regulates T cell-mediated immunopathology
(a-c) C57BL/6 animals received 10 Gy total body irradiation followed by injection of 3×106 T cells along with 5×106 TCD-BM cells from either syngeneic C57BL/6 or allogeneic BALB/c donors. Transcriptome analysis of colonic IECs from syngeneic and allogeneic recipients 7days post HCT. Heatmap of OXPHOS pathway gene (a) and TCA cycle related gene (b). (c) The mRNA expression of Sdha (left), Sdhb (middle) and Sdhc (right) in IECs from syngeneic and allogeneic recipients (n = 3 biologically independent animals). The p-values of the transcriptome analysis (c) obtained from DESeq-analysis (mean ± s.e.m.).
