Fig. 1: Demographics and neutralization titers of children with COVID-19 or MIS-C.
From: SARS-CoV-2 immune repertoire in MIS-C and pediatric COVID-19
a, Overview of pediatric cohort, including hospitalized mild/moderate or severe control (SARS-CoV-2 negative) and children with mild/moderate (M) or severe (S) COVID-19 or MIS-C. b, Spearman correlations of clinical parameters among the groups assigned according to clinical disease severity was performed using R on log-transformed data. Color intensity and size of the circles are proportional to the correlation coefficients. Heat scale in the correlogram ranges from −0.7 (blue; negative correlation) to +0.7 (red; positive correlation). Statistical analyses among groups were performed using R and differences were considered statistically significant with a 95% confidence interval when the P value was less than 0.05 (*P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001, ****P ≤ 0.0001). Original P values that show significance are marked on the circles. A black box around the circle indicates the adjusted P value of false discovery rate (FDR) < 0.05. c, Violin plots of SARS-CoV-2 serum PsVNA50 across clinical groups, as determined by spike PsVNA. Each dot represents a distinct patient color coded by groups: gray, mild/moderate control (n = 9); black, severe control (n = 5); orange, mild/moderate COVID-19 (n = 20); red, severe COVID-19 (n = 15); cyan, mild/moderate MIS-C (n = 8); blue, severe MIS-C (n = 17). Statistical analyses among groups were performed using R. The tests were two-sided using Tukey multiple-group comparisons to reduce type 1 error. The differences were considered statistically significant with a 95% confidence interval when the P value was less than 0.05 (*P ≤ 0.05, ** P ≤ 0.01, ***P ≤ 0.001, ****P ≤ 0.0001). Detailed statistical data are provided in Supplementary Table 9. d, Correlation and linear regression of serum neutralization titers with DPoS in children with MIS-C and COVID-19. The associated Pearson’s correlation coefficients (r) and linear regression significance (P) are colored accordingly. The trend line fits are shown as center solid lines with the error bands representing the 95% confidence intervals shown as shaded colored areas. ALC, absolute lymphocyte count; ALT, alanine aminotransferase test; ANC, absolute neutrophil count; BNP, brain natriuretic peptide; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; WBC, white blood cell.
