Extended Data Fig. 5: SARS-CoV-2 immunodominant epitope profile of children with COVID-19 or MIS-C.
From: SARS-CoV-2 immune repertoire in MIS-C and pediatric COVID-19
(a) Heat map of immunodominant sites (≥3 clonal frequency in at least one sample) on the SARS-CoV-2 proteome. IgM, IgG and IgA antibodies in mild (M) or severe (S) serum samples from COVID-19, MIS-C patients or severe control (c) samples identified using GFPDL analyses. The immunodominant sites on the left indicate amino acid residue of the antigenic sites and the region it encompasses on the proteome in parentheses. Color scale on the left represents range of clonal occurrences (frequency) of each site. Heat map was generated using R. Significant values for frequency of sites recognized by mild vs. severe COVID-19 and severe COVID-19 vs. severe MIS-C and mild vs. severe MIS-C samples for IgG and IgA were determined by Unpaired t-test and are color coded (white-n.s., light grey-p < 0.05, grey-p < 0.01, dark grey-p < 0.001, black-p < 0.0001). (b) Frequency of clones of each of statistically significant IgG or IgA differential sites between mild vs severe COVID-19 or MIS-C is shown for all disease cohorts.
