Extended Data Fig. 9: Relationship of SARS-CoV-2 serum antibody binding and clinical symptom scores.
From: SARS-CoV-2 immune repertoire in MIS-C and pediatric COVID-19
Total binding antibody (Max RU) of serum sample from SARS-CoV-2 infected children against the 28 purified SARS-CoV-2 protein and prefusion spike proteins from other coronaviruses or RSV prefusion-F or H1N1 influenza HA on all children sera with COVID-19 and MIS-C, regardless of disease severity were plotted with corresponding pSOFA score. Each dot represents a unique patient antibody binding and associated pSOFA score: orange, Mild/moderate COVID-19 (n = 20); red, Severe COVID-19 (n = 15); cyan, Mild/moderate MIS-C (n = 8); blue, Severe MIS-C (n = 17). Linear regression was performed across all SARS-CoV-2 infected children, regardless of disease severity. Black line indicates the regression line for all patients. Associated Pearson’s correlation coefficients (r) and linear regression significance (p) are shown. The trendline is depicted as solid black line with the error bands representing 95% confidence interval shown as shaded area.
