Extended Data Fig. 10: Relationship of SARS-CoV-2 serum antibody avidity and clinical disease severity.
From: SARS-CoV-2 immune repertoire in MIS-C and pediatric COVID-19
Antibody avidity (off rates; 1/sec) of serum sample from children against the 28 purified SARS-CoV-2 protein and prefusion spike proteins from other coronaviruses or RSV prefusion-F or H1N1 influenza HA on all the days post-enrollment, regardless of disease severity were plotted with corresponding pSOFA score. Each dot represents a unique patient antibody off-rate and associated pSOFA score: Orange, Mild/moderate COVID-19 (n = 20); Red, Severe COVID-19 (n = 15); cyan, Mild/moderate MIS-C (n = 8); Blue, Severe MIS-C (n = 17). The linear regression analysis was performed across all SARS-CoV-2 infected children, regardless of disease severity. Black line indicates the regression line for all patients. Associated Pearson’s correlation coefficients (r) and linear regression significance (p) are shown. The trendline is depicted as solid black line with the error bands representing 95% confidence interval shown as shaded area.
