Fig. 5: Immune markers of disease severity in children with COVID-19 or MIS-C.
From: SARS-CoV-2 immune repertoire in MIS-C and pediatric COVID-19
a–d, Correlation and linear regression of serum neutralization titers (a), cytokines (b), total antibody binding (c) and antibody avidity (d) for the first-drawn time-point sample for each patient, with corresponding maximum pSOFA clinical disease-severity scores across all pediatric MIS-C and COVID-19 groups, regardless of disease-severity classification across all SARS-CoV-2-infected children. The associated Pearson’s correlation coefficients and linear regression significance values are shown. Each dot represents a unique patient antibody binding and associated pSOFA score: orange, mild/moderate COVID-19 (n = 20); red, severe COVID-19 (n = 15); cyan, mild/moderate MIS-C (n = 8); blue, severe MIS-C (n = 17). The black center lines indicate the trend lines for all patients with the error bands representing 95% confidence intervals, shown as shaded areas. e, PCA for antibody binding and avidity to selected SARS-CoV-2 proteins (prefusion spike, NSP5, ORF3a, ORF5 (M) and ORF9c) of the first-drawn serum samples collected from 74 children. The percentage of variables explained by each principal component is indicated in the parenthesis. Points are colored by sample groups: gray, mild/moderate control; black, severe control; orange, mild/moderate COVID-19; red, severe COVID-19; cyan, mild/moderate MIS-C; blue, severe MIS-C. Ellipses show the 95% confidence interval around the colored centroid for each group. f, The top five antibody variables describing component loadings (PC1 and PC2) of PCA analysis are shown in the loading plots.
