Extended Data Fig. 8: Phenotypes of mice with mutations impairing Roquin-1 interaction with Regnase-1.
From: Disrupting Roquin-1 interaction with Regnase-1 induces autoimmunity and enhances antitumor responses
Contour plots of flow cytometry analysis of CD4+ T cells (a), TFH cells (b) and GC B cells (c) from spleens of 9-14 weeks old WT, Rc3h1M199R/fl;Cd4-Cre, Rc3h1M199R/fl;Vav-Cre and Rc3h1M199R/M199R mice. Contour plots are representative of WT, Rc3h1M199R/M199R: n = 6, Rc3h1M199R/fl; Cd4-Cre, Rc3h1M199R/fl; Vav-Cre: n = 5 (a), or WT, Rc3h1M199R/M199R: n = 8, Rc3h1M199R/fl; Cd4-Cre: n = 6, Rc3h1M199R/fl; Vav-Cre: n = 7 (b, c) analyzed mice in at least 3 independent experiments.
