Fig. 2: Intravenous BCG vaccination uniquely elicits a robust lung-compartmentalized antibody response. | Nature Immunology

Fig. 2: Intravenous BCG vaccination uniquely elicits a robust lung-compartmentalized antibody response.

From: Robust IgM responses following intravenous vaccination with Bacille Calmette–Guérin associate with prevention of Mycobacterium tuberculosis infection in macaques

Fig. 2

a–c, Fold change values in IgG1 (a), IgA (b) and IgM (c) titers present in the BAL fluid of each rhesus macaque following BCG vaccination. Fold changes were calculated as the fold change in Luminex MFI over the pre-vaccination level for each macaque. A base-2 log scale was used for the y axis. Each point represents the duplicate average from a single macaque. The lines represent group medians over time. Kruskal–Wallis with Dunn’s multiple-comparison tests were performed on the fold change values at each time point, comparing each experimental BCG vaccination group to the standard-dose i.d. BCG group. Adjusted P values < 0.05 compared to the standard-dose i.d. BCG group are shown and are colored by vaccination group.

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