Extended Data Fig. 8: T1D autoantigens with different antigen-specific CD8+ T cell frequencies and clonality between healthy subjects and T1D patients.
From: High-throughput and high-dimensional single-cell analysis of antigen-specific CD8+ T cells
a, Five T1D autoantigens were identified to have a significantly higher frequency of antigen-specific T cells in peripheral blood when the MID-negative threshold was set to 15. A two-sided Wilcoxon nonparametric test was performed. Horizontal lines represent 25th percentile, median and 75th percentile values, with whiskers extending to the farthest data point within a maximum of 1.5 × interquartile range. The number of subjects with HLA-A01:01, A02:01 and B08:01 are 10, 12 and 10, respectively. b, TCR clonality heatmap of T1D antigenic-specific T cells for each antigen/donor combination. Grey, no T cells were detected.
