Extended Data Fig. 4: Loss of circadian rhythmicity of phagocytosis gene expression in aged macrophages.
From: Aging disrupts circadian gene regulation and function in macrophages
a. Heatmap of normalized CLEAR network gene expression values of all time points for each age group shows a decrease in overall gene expression in aged as compared to young peritoneal macrophages. b. Circadian RNA-seq expression patterns of phagocytosis-related genes reveal loss of rhythmicity in aged peritoneal as compared to young macrophages. Data are mean ± s.e.m, n = 21 mice in each age group and n = 3 in each time group. Indicated p-values were calculated by JTK_CYCLE on normalized expression values.
