Fig. 1: Single-cell transcriptomic analysis of B cell response to BNT162b2 vaccination.
From: BNT162b2 vaccine induces divergent B cell responses to SARS-CoV-2 S1 and S2
a, Outline of experimental approach. b–d, Single-cell transcriptome analysis. UMAP visualization of B cell clusters for all individuals at four time points (b). Cluster assignments are based on gene expression and cell surface expression (CITE-seq) of canonical B cell markers. Mean percentages of B cell clusters shown in b (c). Individual and mean percentages of B cell clusters in b at four time points (d). n = 9 individuals at all time points. Individual values, means and s.d. are shown. Exact P values were obtained by two-tailed one-way analysis of variance (ANOVA), followed by Dunnett’s multiple comparison test. Bdn cells, double-negative B cells.
