Fig. 1: Children and adults develop coordinated antibody responses to SARS-CoV-2.
a, SARS-CoV-2 antibody levels measured by MSD assay in children (n = 91) and adults (n = 154). Serostatus was assigned based on spike serology and used to divide the cohorts into seropositive (red/blue) and seronegative (light red/light blue) (seropositive/negative children n = 43/48, adults n = 91/63, respectively). The dotted lines represent cutoff values for serostatus. Fold change indicates the difference between the GMTs in seropositive children and adults. The bars indicate the geometric mean with 95% confidence interval (CI). b, The level of the spike- and nucleocapsid-specific antibody response was correlated within individual donors and revealed a coordinated response to both proteins. a.u., arbitrary unit.
