Extended Data Fig. 5: mTORC2-deficiency induces ferroptosis in both memory TH1 and TFH CD4+ T cells. | Nature Immunology

Extended Data Fig. 5: mTORC2-deficiency induces ferroptosis in both memory TH1 and TFH CD4+ T cells.

From: The kinase complex mTORC2 promotes the longevity of virus-specific memory CD4+ T cells by preventing ferroptosis

Extended Data Fig. 5

a, Bodipy C11 intensity on either wild-type SMARTA (blue) or Rictor−/−-SMARTA (red) TH1 and TFH cells in spleens of recipients at day 60 post infection of LCMV Arm+. The presented data are representative of three independent experiments (n=5 for WT, n=6 for Rictor−/−). b, Bodipy C11 intensity on bulk memory TH1 (CD25−GITR−CD44highCXCR5−CD4+) and TFH (CD25−GITR−CD44highCXCR5+CD4+) cells in spleens of either Rictorfl/fl (blue) or ERT2Cre-Rictorfl/fl (Rictor−/−, red) mice after administration of Tamoxifen. The data presented are representative of three independent experiments (n=4). Data are presented as mean values ± SD and analyzed by unpaired two-tailed t-test in a-b.

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