Extended Data Fig. 8: GSEA reveals hyperactive mitochondrial ROS generation in mTORC2-deficienct memory CD4+ T cells. | Nature Immunology

Extended Data Fig. 8: GSEA reveals hyperactive mitochondrial ROS generation in mTORC2-deficienct memory CD4+ T cells.

From: The kinase complex mTORC2 promotes the longevity of virus-specific memory CD4+ T cells by preventing ferroptosis

Extended Data Fig. 8

a, b, c, GSEA plots for GO term about mitochondrial organization and respiratory chain complex assembly (a), cellular regulation of reactive oxygen species metabolic process (b), and cellular oxidative stress (c) in sorted memory TH1 cells (CD25−GITR−CD44highCXCR5−CD4+) and memory TFH cells (CD25−GITR−CD44highCXCR5+CD4+) from either CD4Cre-Rictorfl/fl (Rictor−/−) or Rictorfl/fl mice at day 60 post-infection of LCMV Arm+. NES, normalized enrichment score; FDR, false discovery rates.

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