Extended Data Fig. 9: Blockade of IL-7 signaling results in mitochondrial dysfunction in memory CD4+ T cells. | Nature Immunology

Extended Data Fig. 9: Blockade of IL-7 signaling results in mitochondrial dysfunction in memory CD4+ T cells.

From: The kinase complex mTORC2 promotes the longevity of virus-specific memory CD4+ T cells by preventing ferroptosis

Extended Data Fig. 9

a, Experimental setup is described as in Extended Data Fig. 6. TMRE, MitoTracker, and MitoSOX intensity on memory SMARTA cells in spleens of recipients at day 60 post LCMV Arm+ infection in the context of IL-7 signaling blockade (αIL-7-mAb) or not (Control). The presented data are representative of two independent experiments (n=4 for αIL-7-mAb, or 5 for Control). Data are presented as mean values ± SD and analyzed by unpaired two-tailed t-test in a.

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