Extended Data Fig. 5: Estimated effects of physicochemical features at each TCRβ position, stratified by CDR3β length.
From: Repertoire analyses reveal T cell antigen receptor sequence features that influence T cell fate
(a) Estimated log odds ratio for Treg fate per standard deviation of each physicochemical feature at each CDRβ(1-3) loop position in each CDR3β length; features with an estimate > 0 are positively associated with Treg fate while features with an estimate < 0 are negatively associated. For each CDR3β length, all effects were estimated jointly in an L2-regularized logistic regression with a penalty weight tuned via 10-fold cross-validation (Methods). (b) Treg odds ratio per standard deviation increase in each physicochemical feature at each CDR3βmr position for each CDR3 length (Methods, Supplementary Table 9). Error bars denote 95% confidence interval for the estimated odds ratio.
