Extended Data Fig. 7: Backbone network analysis identify downregulated TGF-β signature during IFN-I response. | Nature Immunology

Extended Data Fig. 7: Backbone network analysis identify downregulated TGF-β signature during IFN-I response.

From: Type I interferon transcriptional network regulates expression of coinhibitory receptors in human T cells

Extended Data Fig. 7

a, Directed TF backbone networks at the early and intermediate waves. The regulation and interaction of each DETFs at each transcriptional wave were depicted. TF footprints enriched in IFN-β condition were highlighted in yellow. b, ssGSEA for TGF-β signaling pathways with upregulated TFs (Up) and downregulated TFs (Down) at each transcriptional wave. Adjusted p values are shown and the dotted line indicates a threshold of significance defined by adjusted p value = 0.05. **p < 0.01, ***p < 0.001. Data was represented with mean + /− SEM.

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