Extended Data Fig. 8: Single cell RNA-seq analysis of LL/2 immune infiltrates. | Nature Immunology

Extended Data Fig. 8: Single cell RNA-seq analysis of LL/2 immune infiltrates.

From: Loss of the intracellular enzyme QPCTL limits chemokine function and reshapes myeloid infiltration to augment tumor immunity

Extended Data Fig. 8

a,b,c,d, Qpctl–/– and Qpctl+/+ littermates were inoculated with Qpctl–/– or Qpctl+/+ LL/2 tumors, respectively. On day 14 after tumor inoculation, tumors were excised and processed for single-cell RNA-seq. a, Number of cells recovered per sample (n = 3). b, UMAP plots of tumor immune infiltrates, from merged samples (n = 6, three samples per genotype). c, Violin plots representing quality control measurements. d, Heatmap showing normalized expression of top 10 expressed genes in each cluster. Bars are medians and symbols represent individual mice. Mono/Mac/DCs: Monocyte/Macrophage/Dendritic Cells.

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